US biotech firm Novavax said Thursday it was initiating its final Phase 3 clinical trial for its experimental COVID-19 vaccine.The trial will be carried out in the United Kingdom and aims to enroll 10,000 volunteers, aged 18-84, with and without underlying conditions, over the next four to six weeks.”With a high level of SARS-CoV-2 transmission observed and expected to continue in the UK, we are optimistic that this pivotal Phase 3 clinical trial will enroll quickly and provide a near-term view of NVX-CoV2373’s efficacy,” said Gregory Glenn, the company’s president of research and development, using the technical name for the formulation. Topics : The company says the drug, which is a liquid formulation, can be stored at two degrees Celsius to eight degrees Celsius, refrigerator temperature.In the spring, the company said it had proven the efficacy of a seasonal flu vaccine it had developed using the same technology. It is the eleventh COVID-19 vaccine candidate to reach the Phase 3 stage globally.The company has been awarded $1.6 billion by the US government to develop and fund the drug, which is administered by two intramuscular injections.The Maryland-based company uses insect cells to grow synthesized pieces of the spike protein of the virus, which it hopes will evoke a robust human immune response.It also uses an “adjuvant,” a compound that boosts the production of neutralizing antibodies.
May 13, 2016 Press Release, Substance Use Disorder Harrisburg, PA – Governor Tom Wolf was joined by Sen. Mario Scavello, Rep. Rosemary Brown, Sen. John Gordner, and Rep. Tarah Toohil, as well as local officials, law enforcement, and health care professionals, at two roundtables today to discuss local and statewide efforts to lead the nation in combating the opioid abuse and heroin use epidemic in Pennsylvania.In an effort to confront this epidemic collaboratively, Governor Wolf is conducting roundtables statewide to discuss the initiatives of his administration, the state legislature, county agencies, treatment centers, hospitals, and medical schools. The Wolf Administration is eager to engage in these local conversations in order to listen to local officials about the challenges that they are facing.“Fighting Pennsylvania’s opioid and heroin epidemic is a top priority for my administration,” said Governor Wolf. “These roundtables are an opportunity to work collaboratively with the General Assembly and community leaders to ensure Pennsylvania leads the nation in the fight to combat the opioid abuse and heroin use crisis.”Governor Wolf was joined by a number of other state and local leaders at events in Stroudsburg and Hazleton, including PA Department of Corrections Secretary John Wetzel and PA Director of Homeland Security Marcus Brown. The governor lauded the efforts of Sen. Mario Scavello and Rep. Rosemary Brown at a roundtable at the Monroe County Public Safety Center this morning. In the afternoon, the governor touted the work of Sen. John Gordner and Rep. Tarah Toohil at Penn State Hazleton.“It is important for all stakeholders to come together to address the ongoing heroin and opioid abuse epidemic in the Commonwealth. The Legislature, the Governor’s Office, local officials, and community leaders need to work together to address the pressing need for prevention and treatment for those affected, said Senator Scavello. “Heroin and opioid abuse affects families, friends, neighbors – it does not discriminate in the victims it chooses. I am pleased to join my colleagues in fighting to address this important health crisis and bring the resources needed to prevent further individuals from being affected.”“Opioid and heroin addiction is a serious state issue, and it is significantly impacting our local community, families, and children here in Monroe and Pike counties. I speak consistently with families affected by addiction, and I am committed to assisting with this issue in any way possible. Currently, I do have legislation introduced (HB1699) to limit prescribing in emergency rooms to help monitor possible addiction and the resale of opioids,” said Representative Brown. “I thank the Governor for making a stop in Monroe County to listen to how this is affecting us locally and to deeper discuss possible real-world solutions and recommendations.”“The heroin and opioid epidemic is affecting every demographic in every community in our Commonwealth,” said Senator Gordner. “I appreciate Governor Wolf’s efforts to commit resources to this problem and I appreciate that he is coming to our community to discuss how we can work together to combat this crisis.”“Clearly, we are up against a formidable enemy. As opioid and heroin abuse grows, we need to aggressively address it in our communities,” said Rep. Toohil. “I commend the governor for coming to Hazleton to raise public awareness about the drug epidemic and discussing possible solutions. There is no doubt, we must all work as one to reduce the number of overdose deaths across the Commonwealth.”The Wolf Administration hopes that these discussions are just the beginning of a larger conversation with both Republicans and Democrats in the House and Senate as well as local officials, law enforcement, emergency responders, and health care professionals.“I look forward to continue working collaboratively with the General Assembly and community leaders to ensure Pennsylvania leads the nation in the fight to combat the opioid abuse and heroin use epidemic,” said Governor Wolf. “The magnitude of the addiction and overdose death epidemic in Pennsylvania is shocking: at least seven Pennsylvanians die every day from a drug overdose. With nearly 2,500 overdose deaths in Pennsylvania in 2014 and estimates that the 2015 total will be higher, a collaborative effort on the federal, state, and local levels is crucial in combating this crisis.”Some of the administration’s initiatives in the fight against heroin include: signing a statewide standing order for naloxone, making it possible for all Pennsylvanians to access this life-saving drug; equipping the Pennsylvania State Police with naloxone so that those troopers who are first on the scene of an overdose can have another tool on-hand during these emergencies; partnering with Adapt Pharma to make Narcan available to public high schools across the state at no cost; developing the ABC-MAP prescription drug monitoring program to detect and prevent prescription fraud and abuse, which contribute to addiction; and appointing a director for the state’s Prescription Drug Monitoring Program (PDMP) Office, who will work to ensure that the PDMP meets its goal of assisting healthcare professionals in identifying patients that would benefit from treatment.In an effort to curtail drug addiction and curb the supply of excess drugs that can be used illicitly, the Department of Health is leading an effort to build upon the opioid prescribing guidelines already created, including specialty specific guidelines for emergency department providers, dentists, obstetricians and gynecologists, and pharmacists. These guidelines give healthcare providers direction for safe and effective pain relief practices, with greater emphasis on non-opioid therapies and greater caution to prevent addiction and diversion. In addition, the DOH recently joined dozens of healthcare organizations, medical experts, and consumer advocacy groups in signing petitions requesting changes to federal pain management requirements that are believed to foster dangerous prescribing practices.The Department of Drug and Alcohol Programs is developing the “warm hand-off” process “warm hand-off” process, whereby overdose survivors would be taken directly from the emergency department to a licensed drug treatment provider, as well as Pennsylvania’s Prescription Drug Take-Back Program. This program helps communities properly dispose of unused prescriptions at any of the 400+ police station locations across Pennsylvania. To date, approximately 40,000 pounds of prescription drugs have been taken back and destroyed.Governor Wolf’s decision to expand Medicaid eligibility in Pennsylvania under the Affordable Care Act has greatly increased access to treatment services for hundreds of thousands of Pennsylvanians.Finally, Governor Wolf’s proposed 2016-17 budget provides more than $34 million to treat more than 11,250 new individuals with substance use disorder. The Department of Human Services will provide 25 new Opioid Use Disorder Centers of Excellence for individuals with substance use disorder, providing medication-assisted treatment and appropriate wraparound services, such as cognitive-based therapies. After this first phase of implementation, there will be a push for 25 more facilities that would have the capacity to treat 22,500 individuals total.# # #Like Governor Tom Wolf on Facebook: Facebook.com/GovernorWolf SHARE Email Facebook Twitter In NEPA, Governor Wolf Continues Roundtables to Address Pennsylvania’s Opioid Epidemic
UK investors have continued to lobby the Debt Management Office (DMO) over the issuance of index-linked Gilts based on the consumer prices index (CPI).The DMO – an executive body of the UK Treasury that manages all Gilt issuance – recently held annual meetings with its Gilt investor base, with the group acknowledging a “growing case” for CPI issuance as the number of pension funds using the measure increases.In the past, it has been reluctant to increase index-linked issuance – or issue CPI-linked paper – due to weak demand and the risk of alienating other customers. However, in 2011, the government changed the official inflation measure for the civil service pension scheme to the CPI. Subsequently, many of the private sector pension funds that followed suit found it increasingly difficult to hedge inflation risk and called on the DMO to help.Government index-linked debt has traditionally been linked to the retail prices index (RPI), but the UK statistics office abandoned it as an official measure after its calculation formula came in for harsh criticism.In the minutes from the DMO’s latest meeting in Edinburgh and London, the body said: “It was noted by some that the growth of CPI linkage within the pension industry was increasing the case for the launch of CPI-linked Gilts in the future. It was suggested the case for their introduction was not necessarily pressing now, but that it was likely that the case for their introduction would increase with the passage of time.”The Edinburgh meeting also concluded the level of index-linked issuance was acceptable.In London, the DMO reported “mixed views” on the need for CPI-linked debt despite acknowledging calls to increase the level of issuance.The UK issued around 23.6% of its £1.44trn (€1.92trn) of debt index-linked, with pension fund and insurance companies owning 26% of total DMO issuance, third behind overseas investors (including pension funds) and the Bank of England after quantitative easing.In an 2014 interview with IPE, DMO chief executive Robert Stheeman said there would be no concrete plans for CPI-linked debt until the demand base became stronger.He added that the office saw index-linked issuance as cost effective, but that it could not issue this exclusively.The National Association of Pension Funds has long called for CPI issuance to help ease the burden of inflation hedging for members forced to increase payments by CPI.Earlier this month, a review by the UK Statistics Authority called on the Office for National Statistics to scrap use of the RPI altogether, including for the issuance of debt.AXA Investment Managers argued that such a move might alienate pension fund investors continuing to uprate pensions by RPI, but added that a duel approach could appease the DMO client base.For more from IPE on inflation hedging and investments, click here.
Shell is interested in entering the UK offshore wind market, Mark Gainsborough, executive vice president at Shell New Energies, told Reuters.The company plans to crack the UK offshore wind market through either acquiring a share in an existing project, acquiring an entire project, or by securing seabed leases later this year, Gainsborough told Reuters in an interview.These plans are expected to proceed in spite of the UK’s intention to leave the European Union at the end of March, Gainsborough said, adding that the most important thing would be for the UK government to continue to provide policies supportive of the offshore wind.Shell established the New Energies division in 2016 and committed to investing USD 1 billion a year in alternative energy sources by the end of the decade.Since then, the energy major has been active in the offshore wind industries in the USA, where the company has several ongoing projects, the Netherlands, and France.The company is also actively supporting the development of kite power energy systems, as well as floating wind technology.
Loading… Former heavyweight champion, Evander Holyfield could add fitness to blessings he reaped from boxing even as he showcased an impressive figure during workout Holyfield who uploading a clip of his grueling kettlebell workout Thursday, is preparing to return to boxing in a charity fight and has been working hard in the gym recently as he bids to prove he is taking a possible comeback seriously He certainly looked in amazing shape as he worked up a sweat after a difficult weights exercise in a video on his Instagram, writing: ‘Feeling stronger than ever. #TEAMHOLYFIELD’ The veteran hasn’t fought since 2011, when he knocked out Brian Nielsen, but he is stepping up efforts to return to the ring for an exhibition match – which would see him follow former opponent Mike Tyson, 54, and Roy Jones Jr, 51, who agreed to fight earlier this summer. Former heavyweight champion, Evander Holyfield shows off impressive figure This week Holyfield also uploaded a clip of him shadow boxing inside the ring, but had fans concerned about getting back into the sport after he showed a slower hand speed. He wrote: ‘Morning training. Sitting at 215lbs, right where I want to be.’Advertisement FacebookTwitterWhatsAppEmail分享 He has also teased boxing fans with videos of him being worked hard with battle ropes, skipping and strength exercises led by ex-heavyweight king Wladimir Klitschko. Holyfield has been sizing up a trilogy fight with Tyson but believes his deal to fight Jones Jr may wreck the possibility of it happening. Read AlsoHow Evander Holyfield won and lost his £240m fortune ‘Mike may have wanted another exhibition before fighting me. By him doing this, it may mess up a future one [against me]. ‘We’d talked about it, but there was nothing solid on paper. We knew we wanted to do it first. ‘When you do it second, people are going to judge how the first one was. Promoted ContentBest Car Manufacturers In The WorldTop 10 Female Stars Everyone Had A Crush On In The 90sWho Is The Most Powerful Woman On Earth?2020 Tattoo Trends: Here’s What You’ll See This YearBirds Enjoy Living In A Gallery Space Created For ThemA Soviet Shot Put Thrower’s Record Hasn’t Been Beaten To This DayCouples Who Celebrated Their Union In A Unique, Unforgettable WayUnderappreciated Movies You Missed In 20198 Superfoods For Growing Hair Back And Stimulating Its Growth9 Facts You Should Know Before Getting A TattooYou’ve Only Seen Such Colorful Hairdos In A Handful Of AnimeBest & Worst Celebrity Endorsed Games Ever Made
Versailles, In. — Ripley County clerk, Ginger Bradford says Wednesday, January 9, 2019, is the first day a person can declare candidacy for the Batesville City Primary Election or the Town of Versailles Primary Election.Batesville residents will elect a mayor, clerk-treasurer, city judge and five (5) common council positions. The Town of Versailles will elect a clerk-treasurer and 1 town council member.Potential candidates must be a registered voter and reside in the district they file in. Candidates may file in the Election Room, 2nd floor of the Courthouse Annex, 102 West First North Street, Versailles. The office is open Monday through Friday, 8 a.m. to 4 p.m.The deadline for filing for these positions is Friday, February 8, by noon.The Town of Sunman and the Town of Napoleon will both elect a clerk-treasurer and three (3) town council members by town convention.Dates for those declaring candidacy for those offices are January 9 until noon on Wednesday, August 1, 2019.For more information about town conventions, please contact your party’s county chairman. For additional questions please call 812-689-4783 with questions.
Martinez could hand Eto’o his full home debut against Palace after the Cameroon veteran once again made an impact off the bench against Wolfsburg, setting up Kevin Mirallas’ late strike. The Everton boss has one concern with full-back Seamus Coleman facing a late fitness test after sustaining a knock on the head in the midweek clash. Palace boss Neil Warnock has backed Phil Jagielka to answer his critics in the only way he knows how – with full-blooded performances for both Everton and England. The 32-year-old defender played in the opening two games of England’s ill-fated World Cup campaign alongside Chelsea’s Gary Cahill but has since lost his place to Phil Jones. Jagielka has also come under fire for some below-par displays at the heart of the Toffees defence as Martinez’s side have shipped 10 goals in the early weeks of the Premier League season. But Warnock has backed the man he brought into professional football at Sheffield United 14 years ago to show he can still cut it in the top flight. ”I think he’s just got to be proud of what he’s achieved really,” Warnock said of his former Blades skipper. ”I had him as a lad and they were telling me he was a right-back or a central midfield player and together we found a position for him. To see him playing at the World Cup was a fantastic achievement for him and he’s a smashing lad with a lovely family. ”The answer to the critics is what he did in the Europa League against Wolfsburg. I thought he was superb and that’s the way to answer people, by turning out and playing. ”I’m sure the Everton fans might be even happier if he doesn’t get picked for England because he does a wonderful job for Everton and has done for many years. I remember talking to David (Moyes) and Arsene Wenger and said, ‘If we (Sheffield United) do get relegated then he’s the one you want to sign’. ”He’s just a level-headed lad. He’ll not even bother about any criticism or anything, he just turns up for training each day. ”Managers have first names on the team sheet every week and he’s one of those and Roberto is lucky to have him. He’s a fabulous player and he’d get in every team in the Premier League, I think.” Warnock will give forward Marouane Chamakh every chance to prove his fitness. The Morocco international has been struggling with a hamstring injury and will not be risked if there is a chance the problem could flare up once more at Goodison Park. Deadline day acquisition Zeki Fryers is still waiting for his Palace debut whilst Kevin Doyle is in contention for his first start and Andrew Johnson could yet feature against one of his former clubs. Roberto Martinez’s men built on last week’s win at West Bromwich Albion with an emphatic 4-1 win over German side Wolfsburg to belatedly get their season up and running. And given the nature of their recent performance the Everton goalkeeper believes tired limbs will be the last thing on his team-mates’ mind as they itch to keep their good run going against Neil Warnock’s side. Howard said: “It’s a positive – if you win you can stay on a good winning streak, and if you lose there’s another game right there for you to prove yourself. “I always think the more you play the less you have to train. Playing games keeps you ticking over and I feel when there’re points to be had, it’s easy to bounce back. “These two results help. Against Leicester, Arsenal and Chelsea we played well but we were just a little bit frail in certain areas. “We also knew if we could beat West Brom then double up and beat Palace we’d be right back in the thick of things so hopefully that will be the case.” Martinez is a big fan of Howard and admitted his disappointment that the American keeper was denied a deserved clean sheet on Thursday due to the visitors’ last minute consolation strike. And while the likes of Romelu Lukaku and Samuel Eto’o will continue hitting the headlines up front, Martinez cannot stress enough how Howard’s presence breeds confidence in the other players. “Tim got a lot of credit in the World Cup for his performance against Belgium, but for Evertonians it was just declaring the obvious,” said Martinez. “They have always seen Tim at that level and I have seen it for 13 months now. He is always focused and has a real concentration, and he is enjoying a very good moment of form.” Tim Howard is convinced his Everton team-mates will not experience a Europa League hangover when they made a quick return to action against Crystal Palace at Goodison Park on Sunday. Press Association
March 12, 2020 Associated Press Share This StoryFacebookTwitteremailPrintLinkedinRedditPONTE VEDRA BEACH, Fla. (AP) — The PGA Tour has decided to scrap the rest of The Players Championship and shut down its other tournaments three weeks.,Tampa Bay Lightning advance to face Dallas Stars in Stanley Cup finals, beating New York Islanders 2-1 in OT in Game 6 The PGA Tour has decided to scrap the rest of The Players Championship and shut down its other tournaments three weeks
(REUTERS) – Magnificent centuries by opener Kraigg Brathwaite and Shai Hope put West Indies in a commanding position against England on the second day of the second Test at Headingley on Saturday.Brathwaite was joined by Hope during a tricky morning session for the visitors when they were 35 for three in reply to England’s 258.The pair shared a 246-run partnership as West Indies, written off after a humiliating innings-and-209-runs defeat in the first test, reached stumps on 329-5, a lead of 71.Brathwaite was eventually bowled by Stuart Broad for 134, a textbook innings which contained 17 fours and two sixes, the second of which took him to his sixth Test century.Roston Chase followed shortly afterwards but Hope moved on to 147 and was joined by Jermaine Blackwood who played aggressively to score 21 not out in 23 balls.Shai Hope celebrates his maiden Test hundred as the fourth-wicket stand grew to 246.West Indies resumed on a muggy morning on 19-1, and with James Anderson swinging the ball at will, another West Indies collapse looked on the cards as two early wickets fell.Nightwatchman Devendra Bishoo departed in the fifth over of the morning, edging one from Anderson who then removed Kyle Hope thanks to a great catch from captain Joe Root at second slip.Brathwaite was then joined by Hope and the duo began to chip away at England’s total, playing with discipline and verve to put away any loose balls from England’s attack.Twice Braithwaite was reprieved with successful reviews after being given out lbw — to Broad when he got an inside edge and to the struggling Moeen Ali — as West Indies moved to 109 for three at lunch.The afternoon session belonged to West Indies as Brathwaite completed his century by launching part-time spinner Tom Westley over long-on for a huge six.Hope offered impressive support and played some beautiful cover drives as he also closed in on a century, reaching 85 at tea as England’s bowlers desperately sought a breakthrough.His maiden Test century arrived in the 70th over of the day when, after pulling Ben Stokes for a boundary, he nudged a single off his hip from the following ball.With Hope set and Blackwood a dangerous hitter, West Indies will hope to build a commanding lead today.ENGLAND 1st innings 258 (B. Stokes 100, J. Root 59; S. Gabriel 4-51, K. Roach 4-71) West Indies 1st innings (Overnight: 19-1)K. Brathwaite b Broad 134K. Powell c Cook b Anderson 5D. Bishoo c Bairstow b Anderson 1K. Hope c Root b Anderson 3S. Hope not out 147R. Chase c Cook b Stokes 5J. Blackwood not out 21Extras (b-4 lb-7 w-2) 13Total (for 5 wickets, 102 overs) 329Fall of wickets: 1-11 K. Powell,2-31 D. Bishoo,3-35 K. Hope,4-281 K. Brathwaite,5-296 R. ChaseTo bat: S. Dowrich, J. Holder, K. Roach, S. GabrielBowling:J. Anderson 23 – 7 – 46 – 3, S. Broad 20 – 2 – 73 – 1,C. Woakes 13 – 2 – 58 – 0, B. Stokes 22 – 8 – 60 – 1(w-2),M. Ali 20 – 3 – 69 – 0, T. Westley 4 – 0 – 12 – 0.
BRIDGETOWN, Barbados (CMC) – Chadwick Walton stroked his 20th first class half-century to steady Jamaica Scorpions but opener Shayne Moseley gathered his second of the match, as Barbados Pride tightened their grip on their final round encounter in the Regional Four-Day Championship here yesterday.Resuming the third day at Kensington Oval on 93 for three, Scorpions rallied to 247 all out in their first innings, with the right-handed Walton top-scoring with 72.West Indies limited overs all-rounder Rovman Powell struck a quick-fire 43 while captain Nikita Miller chipped in with 27.Left-arm spinner Jomel Warrican grabbed the last three Scorpions wickets to end with three for 34, while off-spinner Roston Chase (2-34) and pacer Justin Greaves (2-36) picked up two wickets apiece.In reply, Moseley hit an unbeaten 87 to close in on his second first-class hundred while Test opener Kraigg Brathwaite made 50 not out, as the hosts finished on 147 without loss.The left-handed Moseley, who made 79 in the first innings, has faced 153 balls in 156 minutes and struck 10 fours and a six.Brathwaite, meanwhile, has counted five fours in 94 balls at the crease.On 33 without loss at tea, the pair controlled the entire final session as Pride stretched their advantage to 327 runs, heading into today’s final day.Earlier, Scorpions survived a wobble at the start of the day to consolidate, thanks to Walton’s enterprise.Paul Palmer, yet to score at the start, fell inside the first 19 balls of the day for two when he edged a drive at Greaves and was caught at the wicket with 16 runs added.His replacement, all-rounder Fabian Allen, was run-out in the following over without scoring, failing to beat Keon Harding’s direct throw from mid-off at the striker’s end.Walton halted the rut, combining with Powell to post 68 for the sixth wicket in an enterprising stand.While Walton faced 82 balls and struck 10 fours and a six, Powell belted six fours and a couple of sixes in a 47-ball cameo.Scorpions suffered two key blows before lunch, however, when Walton was caught around the corner at leg slip by Shamarh Brooks off Chase half-hour before the break, and Powell was taken at mid-wicket by Greaves off the same bowler, four overs later.Tottering on 200 for seven at lunch, it was left to Miller with four boundaries in a 57-ball knock, to get the visitors closer to 250.PRIDE 1st innings 427SCORPIONS 1st innings (o/n 93 for three)J. Campbell c wkp. Dowrich b Holder 16C. Walton c Brooks b Chase 72A. McCarthy c wkp. Dowrich b Harding 3J. Blackwood b Greaves 39P. Palmer c wkp. Dowrich b Greaves 2F. Allen run-out 0R. Powell c Greaves b Chase 43D. Green c Brooks b Warrican 19N.. Miller c Greaves b Warrican 27M. Mindley c Drakes b Warrican 13C. Lamont not out 0Extras: (b-4, lb-3, w-1, nb-5) 13Total: (all out, 56.3 overs) 247Fall of wickets: 1-21, 2-38, 3-93, 4-109, 5-115, 6-183, 7-196, 8-214, 9-241.Bowling: Harding 6-0-52-1, Holder 9-0-44-1, Drakes 9-0-40-0, Greaves 6-1-36-2, Warrican 15.3-4-34-3, Chase 11-0-34-2.PRIDE 2nd inningsK. Brathwaite not out 50S. Moseley not out 87Extras: (b-4, nb-1, pen-5) 10Total: (without loss, 41 overs) 147Bowling: Mindley 3-0-10-0, Green 2-0-9-0, Powell 1-0-5-0, McCarthy 7-2-17-0, Lamont 7-0-24-0, Miller 11-1-43-0, Campbell 10-3-30-0.Position: Pride lead by 327 runs with all 10 second innings wickets intact.